Genetic Association between Low Expression Phenotype of CD62L (L-selectin) in Peripheral CD4⁺ T Cells and the thid (T-helper Immunodeficiency) Phenotype in the LEC Rat

Abstract

Genetic linkage analysis was performed between the low expression phenotype of peripheral CD4⁺ T cells and the thid (T-helper immunodeficiency) phenotype using (BN × LEC)F ₁ × LEC backcross progenies. In contrast to a previous result using a thid congenic strain that the low expression phenotype of CD62L was not correlated with the thid phenotype, our result in this study indicated that the low expression phenotype of CD62L was genetically linked with the thid phenotype. The discrepancy between the previous and present results may be due to the source of animals, congenic strain versus backcross progenies. It is suggested by this study that the thid locus controls the expression level of CD62L in peripheral CD4⁺ T cells.