抄録
To determine the effects of high temperature on the number of alveolar macrophages (AMs) in bronchoalveolar lavage (BAL) fluid in rats, F344 rats were housed in environment chambers at 23°C, 30°C or 35°C for up to 14 days. The number of AMs in the BAL fluid was significantly decreased in rats housed at 35°C on days 7 and 14, compared to the control group housed at 23°C. The total protein content and lactate dehydrogenase activity did not change at high temperatures in BAL supernatant, indicating that there was no increase in alveolar/capillary barrier permeability or lung cellular injury. The results might suggest that high temperature (35°C) affects the pulmonary defense mechanism.
