Malignant NK/T-Cell Lymphoma Associated with Simian Epstein-Barr Virus Infection in a Japanese Macaque (Macaca fuscata)

Juri SUZUKI; Shunji GOTO; Akino KATO; Chihiro HASHIMOTO; Norikatsu MIWA; Satomi TAKAO; Takafumi ISHIDA; Ayumi FUKUOKA; Hiroyuki NAKAYAMA; Kunio DOI; Koichi ISOWA

doi:10.1538/expanim.54.101

Note

Malignant NK/T-Cell Lymphoma Associated with Simian Epstein-Barr Virus Infection in a Japanese Macaque (Macaca fuscata)

Juri SUZUKI, Shunji GOTO, Akino KATO, Chihiro HASHIMOTO, Norikatsu MIWA, Satomi TAKAO, Takafumi ISHIDA, Ayumi FUKUOKA, Hiroyuki NAKAYAMA, Kunio DOI, Koichi ISOWA

Author information

Juri SUZUKI
Primate Research Institute, Kyoto University
Shunji GOTO
Primate Research Institute, Kyoto University
Akino KATO
Primate Research Institute, Kyoto University
Chihiro HASHIMOTO
Primate Research Institute, Kyoto University
Norikatsu MIWA
Primate Research Institute, Kyoto University
Satomi TAKAO
Graduate School of Science, University of Tokyo
Takafumi ISHIDA
Graduate School of Science, University of Tokyo
Ayumi FUKUOKA
Graduate School of Agricultural and Life Sciences, University of Tokyo
Hiroyuki NAKAYAMA
Graduate School of Agricultural and Life Sciences, University of Tokyo
Kunio DOI
Graduate School of Agricultural and Life Sciences, University of Tokyo
Koichi ISOWA
Japan Bioscience Center Co., Ltd.

Keywords: Japanese macaques, malignant lymphoma, simian Epstein-Barr virus

JOURNAL OPEN ACCESS

2005 Volume 54 Issue 1 Pages 101-105

DOI https://doi.org/10.1538/expanim.54.101

Details

Abstract

A case of spontaneous malignant lymphoma in a Japanese macaque (Macaca fuscata) was pathologically, etiologically and virologically studied. Nasal cavity was involved in the neoplastic lesions in addition to lymphoid and visceral tissues. Histopathological analyses revealed the presence of neoplastic cells classified into histiocytic Hodgkin-like cells and Reed-Sternberg-like cells. Histiocytic Hodgkin-like cells were CD16+ and CD20+, and the CD16+ cells were also positive for simian Epstein-Barr virus (sEBV)-encoded early RNA transcripts. RS-like cells were negative for CD3, CD16 and CD20. Antibodies to early antigen of sEBV were detected, while antibodies to simian T-cell leukemia virus-1 were negative. The case may correspond to EBV-associated nasal type NK/T-cell lymphoma in humans rather than Hodgkin lymphoma.

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