Experimental Animals
Online ISSN : 1881-7122
Print ISSN : 1341-1357
ISSN-L : 0007-5124
Original
Effect of Human Erythropoietin (hEPO) Treatment on Anemia in ICR-derived Glomerulonephritis (ICGN) Mice
Yohei MIYAMOTOKeiko KURAMITSU-MIYAMOTOEma IWANAGAKozue UCHIO-YAMADAMisuzu YAMAGUCHI-YAMADAAtsuo OGURANoboru MANABE
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JOURNAL FREE ACCESS

2005 Volume 54 Issue 2 Pages 181-184

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Abstract

ICR-derived glomerulonephritis (ICGN) mice are a novel inbred strain with hereditary nephrotic syndrome and are thus considered a good animal model of human idiopathic nephrotic syndrome. In the present study, we investigated the effect to erythrocyte production by human erythropoietin (hEPO) treatment in ICGN mice during the early nephrotic stage. Erythrocyte count, hemoglobin concentration and hematocrit value in hEPO-treated (5 U/body/day, for 5 days) ICGN mice were recovered to the levels found in normal ICR mice. In addition, there was no correlation between plasma creatinine level, a marker of renal function, and erythrocyte count after hEPO treatment. Therefore, anemia in ICGN mice may be caused by decreased production of EPO in the kidney following progressive parenchymal damage.

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© 2005 Japanese Association for Laboratory Animal Science
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