Experimental Animals
Online ISSN : 1881-7122
Print ISSN : 1341-1357
ISSN-L : 0007-5124
Original
Quantitative Trait Loci Determining Weight Reduction of Testes and Pituitary by Diethylstilbesterol in LEXF and FXLE Recombinant Inbred Strain Rats
Masayoshi TACHIBANALingmin LUHiroshi HIAIAtsushi TAMURAYoshibumi MATSUSHIMAHayase SHISA
Author information
JOURNALS FREE ACCESS

2006 Volume 55 Issue 2 Pages 91-95

Details
Abstract

Increasing exposure to environmental endocrine disruptor, xeno-estrogen, is a serious hazard to male reproductive activity. To explore possible genetic control in susceptibility to xeno-estrogen, the weight reduction of testes induced by the continuous administration of a synthetic estrogen, diethylstilbesterol, were investigated by quantitative trait analysis in LEXF and FXLE recombinant inbred strain rats, consisting of 21 independent strains, 9 of their substrains, parental F344/Stm and LE/Stm strains, and (F344 × LE)F1. For the weight of testes, one highly significant quantitative trait locus (QTL) and one significant QTL were mapped on chromosomes 7 and 1, respectively. The QTL on chromosome 7 is closely associated with c-myc. Pituitary weight and serum prolactin were also variable among recombinant inbred strains, but no QTL was detected for them in this study.

Information related to the author
© 2006 Japanese Association for Laboratory Animal Science
Previous article Next article
feedback
Top