Experimental Animals
Online ISSN : 1881-7122
Print ISSN : 1341-1357
ISSN-L : 0007-5124
Original
Effects of Air Transportation Cause Physiological and Biochemical Changes Indicative of Stress Leading to Regulation of Chaperone Expression Levels and Corticosterone Concentration
SunBo SHIMSeHyun LEEChuelKyu KIMByoungGuk KIMSeungWan JEESuHae LEEJiSoon SINChangJoon BAEJong-Min WOOJungSik CHOEonPil LEEHaeWook CHOIHongSung KIMJaeHo LEEYoungJin JUNGByungWooK CHOKabRyong CHAEDaeYoun HWANG
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JOURNAL FREE ACCESS

2009 Volume 58 Issue 1 Pages 11-17

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Abstract

Laboratory animals generally experience numerous unfamiliar environmental and psychological influences such as noises, temperatures, handling, shaking, and smells during the process of air transportation. To investigate whether stress induced by air transportation affects stress-related factors in animals, the levels of hormone and chaperone protein were measured in several tissues of F344 rats transported for 13 h and not transported. Herein, we conclude that the levels of corticosterone, HSP70, and GRP78 were significantly increased in the transported group compare to not transported group, but they were rapidly restored to the not transported group level after a recovery period of one week. However, the magnitude of induction and restoration levels of these factors varied depending on the tissue type. Thus, these results suggest that air transportation should be considered for the improvement of laboratory animal health and to reduce the incidence of laboratory animal stress.

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© 2009 Japanese Association for Laboratory Animal Science
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