Experimental Animals
Online ISSN : 1881-7122
Print ISSN : 1341-1357
Differential Age-Related Bone Architecture Changes between Female and Male STR/Ort Mice
Kentaro UchidaKen UrabeKouji NaruseYusuke KozaiKenji OnumaYuko Mikuni-TakagakiIsamu KashimaMasaki UenoRina SakaiMoritoshi ItomanMasashi Takaso
Author information

2012 Volume 61 Issue 1 Pages 59-66


The incidence of spontaneous osteoarthritis (OA) in female STR/Ort mice is much lower than that observed in male STR/Ort mice; however, the reason for the differential incidence of OA between sexes has not been elucidated. Here, we investigated and compared age- and sex-related bone mineral density and architectural changes in male and female STR/Ort mice. Bone architecture and bone mineral density (BMD) of femurs were examined in 5-, 10-, 15-, 20-, and 35-week-old male and female STR/Ort mice by microscopic computed tomography (μCT). Angular degrees of internal tibial torsion (ADITT) were also measured in mice at 5, 15, and 35 weeks of age. Earlier decreases of cancellous volume and BMD were found in male STR/Ort mice. Using μCT, an age-related decline of bone marrow space in femoral diaphysis was observed in both males and females but was more dramatic in females. In addition, an earlier increase of ADITT was observed in male STR/Ort mice, suggesting that internal rotation of the tibia may contribute to OA. Age- and sex-related bone architectural changes clearly differ between male and female STR/Ort mice. These differences in bone structure, particularly ADITT, may explain the differential incidence of OA in STR/Ort mice.

Information related to the author
© 2012 Japanese Association for Laboratory Animal Science
Previous article Next article