Experimental Animals
Online ISSN : 1881-7122
Print ISSN : 1341-1357
ISSN-L : 0007-5124
Comparative study of behavioural tests in the SOD1G93A mouse model of amyotrophic lateral sclerosis
Sara OLIVÁNAna Cristina CALVOAmaya RANDOMaría Jesús MUÑOZPilar ZARAGOZARosario OSTA
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2015 Volume 64 Issue 2 Pages 147-153


In preclinical trials, a sensitive functional test is required to detect changes in the motor behaviour of the SOD1G93A mouse model of amyotrophic lateral sclerosis (ALS). We evaluated changes in body weight and motor impairment in behavioural tests, such as the rotarod, the hanging-wire test and the treadmill, of transgenic and wild type mice. We found differences in detection of the onset of symptoms and progression of the disease between the different tests assessed. Moreover, the data showed significant gender differences in the motor behaviour of this mouse model. The rotarod and the hanging-wire test were more sensitive to detect early motor impairment. Moreover, the results suggested that the rotarod and hanging-wire became the most accurate tests rather than treadmill to characterise the ALS disease phenotype.

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© 2015 Japanese Association for Laboratory Animal Science
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