Experimental Animals
Online ISSN : 1881-7122
Print ISSN : 1341-1357
ISSN-L : 0007-5124
Review
Factors controlling sperm migration through the oviduct revealed by gene-modified mouse models
Yoshitaka FujiharaHaruhiko MiyataMasahito Ikawa
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2018 Volume 67 Issue 2 Pages 91-104

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Abstract

Mammalian fertilization is comprised of many steps including sperm survival in the uterus, sperm migration in the female reproductive tract, physiological and morphological changes to the spermatozoa, and sperm-egg interaction in the oviduct. In vitro studies have revealed essential factors for these fertilization steps for over half a century. However, the molecular mechanism of fertilization has recently been revised by the emergence of genetically modified animals. Here, we focus on essential factors for sperm fertilizing ability and describe recent advances in our knowledge of the mechanisms of mammalian fertilization, especially of sperm migration from the uterus into the oviduct.

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© 2018 Japanese Association for Laboratory Animal Science
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