Experimental Animals
Online ISSN : 1881-7122
Print ISSN : 1341-1357
ISSN-L : 0007-5124
Young Investigator Award
Role of MafB in macrophages
Michito HamadaYuki TsunakawaHyojung JeonManoj Kumar YadavSatoru Takahashi
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JOURNALS OPEN ACCESS

2020 Volume 69 Issue 1 Pages 1-10

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Abstract

The transcription factor MafB regulates macrophage differentiation. However, studies on the phenotype of Mafb-deficient macrophages are still limited. Recently, it was shown that the specific expression of MafB permits macrophages to be distinguished from dendritic cells. In addition, MafB has been reported to be involved in various diseases related to macrophages. Studies using macrophage-specific Mafb-deficient mice show that MafB is linked to atherosclerosis, autoimmunity, obesity, and ischemic stroke, all of which exhibit macrophage abnormality. Therefore, MafB is hypothesized to be indispensable for the regulation of macrophages to maintain systemic homeostasis and may serve as an innovative target for treating macrophage-related diseases.

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© 2020 Japanese Association for Laboratory Animal Science
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