Elevated maternal retinoic acid-related orphan receptor-γt enhances the effect of polyinosinic–polycytidylic acid in inducing fetal loss

Saki TOME; Tetsuya SASAKI; Satoru TAKAHASHI; Yosuke TAKEI

doi:10.1538/expanim.19-0038

この記事には本公開記事があります。本公開記事を参照してください。
引用する場合も本公開記事を引用してください。

Elevated maternal retinoic acid-related orphan receptor-γt enhances the effect of polyinosinic–polycytidylic acid in inducing fetal loss

Saki TOME, Tetsuya SASAKI, Satoru TAKAHASHI, Yosuke TAKEI

著者情報

キーワード: abortion, IL-17, maternal immune activation, poly(I:C), RORγt

ジャーナルフリー早期公開

論文ID: 19-0038

DOI https://doi.org/10.1538/expanim.19-0038

この記事には本公開記事があります。

The final version of this article is now available: Vol. 68 (2019), No. 4 pp. 491-497

詳細

抄録

T helper 17 (Th17) cells have been suggested to play a crucial role in various complications during pregnancy by participating in maternal immune activation (MIA). To test a possible role for Th17 cells in MIA-mediated abortion, we analyzed transgenic mice overexpressing retinoic acid-related orphan receptor gamma-t (RORγt), a master regulator of IL-17 producing cell development. These mutant mice (RORγt Tg mice) exhibited a constitutive upregulation of serum interleukin-17A (IL-17A) and decreased E-cadherin expression in cell–cell junctions of placental tissues. Abortion after the administration of a viral-mimicking synthetic double-stranded RNA polyinosinic–polycytidylic acid was more frequent in RORγt Tg mice than wild-type mice. These results suggest that excessive Th17 cell activity alters immune responsiveness and increases the rate of abortion during gestation.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）