血清反応によるマウス繁殖集団における感染検出の試み

抄録

An attempt was made to check with retired breeder mouse sera, Corynebacteriosis, Salmonellosis, Tyzzer's disease and infections due to mouse hepatitis virus (MHV (Pr) ) and Sendai virus. Of 1, 530 sera collected in March and April 1967 from 13 commercial and institutional breeding colonies, 5 (0.3%) and 19 (1.2%) were shown to have antibodies to Tyzzer's agent and MHV (Pr) respectively by complement fixation test with each infected liver antigen. Of 1, 338 sera of mice which had not received Sendai virus vaccine, 305 (22.7%) showed positive CF reaction to the virus antigen, and in some colonies more than 80% of mice were found to be infected with this virus, In these colonies showing a highly epidemic pattern, respiratory disorders were noticed clinically and pneumonia was observed frequently at autopsy. Agglutinin against Corynebacterium kutscheri was detected in 112 of 1530 (7.3%) sera at high titers, while the antibody against Salmonella enteritidis was demonstrated only in 2 sera of a single colony. In many of mice showing positive serology to Corynebacterium antigen were detected severe lesions as gross abscess in the liver, kidney and lung as well as purulent nephritis.