EXPERIMENTAL ANIMALS
Online ISSN : 1884-4170
Print ISSN : 0007-5124
ISSN-L : 0007-5124
Artificial Nursing of New-born Cynomolgus Monkeys as a Model of the Human Infant and Development of Abnormal Behavior
Hiroshi WAKOTomiji HATAKEYAMAMitsuo KAMIHARASachiko WADAShigeo HONJOTooru FUJIWARAFumiaki CHO
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JOURNAL FREE ACCESS

1975 Volume 24 Issue 4 Pages 161-171

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Abstract
New-born cynomolgus monkeys were successfully reared by artificial nursing that was started just afterbirth with a 12% solution of a commercially prepared powderedmilk (Yukijirushi, P 7a) containing 13.3g of protein per 100g. Marked growthretardation was observed in baby cynomolgus monkeys fed on a 12% solution of the modified P 7a milk containing only 6.6g of protein per 100g to which lactose was supplemented to give a baby monkey the same caloric value as that of the original P 7a milk. These artificially reared cynomolgus monkeys manifested various kinds of abnormal behavior such as self-clasping, autism-like self mouthing, huddling, stereotype rocking, head-knocking, autoerotism, fear, aggression, etc.. Generally, develop ment of these abnormal behaviors was more noticeable in the monkeys nursed with a milk bottle fixed to the side of a cage without human contact than in the monkeys nursed by a care-taker with bodily touching. These qualitative observational results indicate that the new-born cynomolgus monkey can be used as a model of the human baby for research into the relationship between malnutrition and abnormal physical and mental growth.
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© Japanese Association for Laboratory Animal Science
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