Effects of the complexes of environmental factors, such as ambient-temperature, relative humidity and air velocity, on the body temperature were investigated in restrained mice. Observations were carried out before and after 60 min-exposure to various triple combinations among environmental temperatures of 15, 25 and 35°C, relative humidities of 40, 65 and 90%, and air velocities of 0.2, 1.0 and 2.0 m/sec. The analysis of variance about the differences of body temperature revealed significant effects of the environmental temperature and the air velocity levels, while no significant effects were recognized of the relative humidity. Effects of the double factors, either the environmental temperature plus the relative humidity or the environmental temperature plus the air velocity, were significant at 5 or 1% level respectively. However, effects of the double factors the relative humidity plus the air velosity, as well as the triple factors were not significant. Under the environments consisted of triple factors, the environmental temperature of 20 and 25°C, the relative humidities of 40 and 70% and the air velocities of 0.1 and 0.5m/sec, significant effects at 1% level were recognized only in the environmental temperature levels. In the relative humidty or the air velocity levels, and the double or triple factor levels, no significant effects were recognized. From the results obtained, the effective temperature (Te) was indicated by the formula, Te=t+100x-v√38-t, in which were given the environmental temperature in t°C, the absolute humidity in x kg/kg and the air velocity in v m/sec.

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Ulcerative entero-colitis was developed in 6-week-old male Sprague-Dawley rats treated daily with ACTH (4mg/kg, s. c.) as well as necrotic purulent lesions in liver, kidney, lung or heart. Incidence of ulcerative lesions was 6.3% in Farm-A rats and 56% in Farm-B rats. Although ulcerative lesions were mostly observed in cecum, the similar lesions were also detected in distal ileum or proximal colon in some cases. Histologically, the lesions were characterized by focal necrosis demarcated from surrounding normal tissue containing a number of clumps of bacteria and cellular debris. Bacteriological examination revealed that provocation ofCorynebacterium kutscheriby ACTH-treatment resulted in appearance of the lesions. By means of intravenous or intraperitoneal inoculation with the strain isolated from lesion similar lesions were produced in the cecum of inoculated rats under the ACTH-treatment.

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New-born cynomolgus monkeys were successfully reared by artificial nursing that was started just afterbirth with a 12% solution of a commercially prepared powderedmilk (Yukijirushi, P 7a) containing 13.3g of protein per 100g. Marked growthretardation was observed in baby cynomolgus monkeys fed on a 12% solution of the modified P 7a milk containing only 6.6g of protein per 100g to which lactose was supplemented to give a baby monkey the same caloric value as that of the original P 7a milk. These artificially reared cynomolgus monkeys manifested various kinds of abnormal behavior such as self-clasping, autism-like self mouthing, huddling, stereotype rocking, head-knocking, autoerotism, fear, aggression, etc.. Generally, develop ment of these abnormal behaviors was more noticeable in the monkeys nursed with a milk bottle fixed to the side of a cage without human contact than in the monkeys nursed by a care-taker with bodily touching. These qualitative observational results indicate that the new-born cynomolgus monkey can be used as a model of the human baby for research into the relationship between malnutrition and abnormal physical and mental growth.

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The present short paper deals with the weight of the male reproductive organs of wild-imported cynomolgus monkeys, including the testes, epididymides, ductus deferens, vesicula seminalis prostata, bulbo urethralis and penis. In addition, the size of the testes and the weight of the thyroid and hypophysis are also presented.

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[in Japanese]

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