Article ID: ffr24-0511
In Japan, approximately 16 million people have osteoporosis, of which approximately 80% are women. Estrogen has a calcium diffusion preventative effect on the bone. Moreover, vitamins, minerals, and proteins influence bone metabolism similarly to hormones. It has been reported that Ca increases the bone strength. However, other minerals have not been investigated in detail. In this study, we used a calciprivia mouse that was subjected to ovariectomy for a laboratory animal and evaluated bone histopathological changes, bone metabolism markers, and bone mineral concentration after administration of Cu-, Zn-, or Mg-containing water. The administration of Mg and Zn after ovariectomy inhibited the development of osteoporosis by restoring bone trabeculae, reducing fat cells in the bone marrow, and normalizing bone metabolism. In contrast, Cu administration may not inhibit the development of osteoporosis owing to increased fat cell area and bone resorption markers, despite restoring bone trabeculae.
