繊維学会誌
Online ISSN : 1884-2259
Print ISSN : 0037-9875
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組紐製小口径絹人工血管の作製とイヌ腹部大動脈移植による評価
早乙女 俊樹上杉 昭二衣笠 純山本 諭岡本 宏之朝倉 哲郎
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2014 年 70 巻 12 号 p. 281-287

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The small-diameter (less than 6.0 mm in diameter) vascular grafts are highly desired due to a large demand of surgical revascularization. In this study, a small-diameter (6mm) vascular graft was prepared with braided Bombyx mori silk fiber tube coated by B. mori silk fibroin aqueous solution, with the goal of achieving sufficient physical strength and good patency of long term. The mechanical properties were evaluated by circumferential tensile test and suture strength test, indicating that the properties were improved remarkably by silk coating. The braiding silk fibroin graft was also evaluated by implantation into the dog abdominal aorta. The color doppler sonography after implantation for 11 months showed that there are neither dilatation nor constriction. At 2 years after implantation of the grafts in dog abdominal aorta, the graft patency and endothelial cell lining of the lumen surfaces were observed. These results demonstrate the feasibility of using braiding silk fibroin vascular graft as a small diameter vascular graft with long term patency.

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© 2014 The Society of Fiber Science and Technology, Japan
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