Abstract
Molecularly imprinted polymeric membranes, bearing a tetrapeptide derivative H-Asp (OcHex)-Val-Asn-Glu (OBzl)-CH2-, were prepared by the membrane preparation (casting) process in the presence of print molecule Ac-L-Trp. The molecularly imprinted polymeric membranes thus obtained showed adsorption selectivity toward the print molecule. The tetrapeptide derivative in the imprinted membranes preferentially recognized Ac-L-Trp from racemic Ac-Trp solutions. The affinity constant between Ac-L-Trp and the chiral recognition site was determined to be 9.7×103 mol-1 dm3 from the adsorption isotherm of Ac-L-Trp in the molecularly imprinted polymeric membrane. Enantioselective electrodialysis was achieved with the present membrane, and the L-isomer was permeated in preference to D-isomer.
