2023 Volume 73 Issue 3 Pages 65-71
Abstract:Nuclear receptors are transcription factors that recognize various lipids as natural ligands. In humans, 48 types of such proteins, including retinoic acid receptors （RARs）, vitamin D receptors （VDR）, estrogen receptors （ERs）, and thyroid hormone receptors （TRs）, have been identified. Although the transcriptional activity of nuclear receptors is primarily regulated by binding to specific ligands, post-translational modifications such as phosphorylation also influence it. Recently, we discovered a novel signaling pathway leading from cell-cell adhesion to serine phosphorylation of several nuclear receptors, contributing to both stem cell differentiation and the malignancy of endometrial cancer and breast cancer. This review will introduce the series of studies that led to these discoveries.
