FUKUSHIMA JOURNAL OF MEDICAL SCIENCE
Online ISSN : 2185-4610
Print ISSN : 0016-2590
ISSN-L : 0016-2590

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Immunotherapy for esophageal squamous cell carcinoma: a review
Kosaku MimuraLeo YamadaDaisuke UjiieSuguru HayaseTakeshi TadaHiroyuki HanayamaAung Kyi Thar MinMasahiko ShibataTomoyuki MommaZenichiro SazeShinji OhkiKoji Kono
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論文ID: 2018-09

この記事には本公開記事があります。
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Cancer vaccines and immune checkpoint inhibitors (ICI) have recently been employed as immunotherapies for esophageal squamous cell carcinoma (ESCC). Cancer vaccines for ESCC have yielded several promising results from investigator-initiated phase I and II clinical trials. Furthermore, a Randomized Controlled Trial as an adjuvant setting after curative surgery is in progress in Japan. On the other hand, ICI, anti-CTLA-4 mAb and anti-PD-1 mAb, have demonstrated tumor shrinkage and improved overall survival in patients with multiple cancer types. For ESCC, several clinical trials using anti-PD-1/anti-PD-L1 mAb are underway with several recent promising results. In this review, cancer vaccines and ICI are discussed as novel therapeutic strategies for ESCC.

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© 2018 The Fukushima Society of Medical Science

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