Regulation of Cell Morphology and Migration by a Rho GTPase Activating Protein FilGAP

抄録

Cell migration is a fundamental process that orchestrates embryonic development and drives cancer invasion and metastasis. Rho small GTPases (Rac, Cdc42, and Rho) regulates cell migration through remodeling of the actin cytoskeleton. Rho GTPase activating proteins (GAPs) are negative regulators of RhoGTPases. FilGAP is a GAP for Rac and binds to Filamin A. Emerging evidences suggest that FilGAP may regulate organization of the actin cytoskeleton in a spatiotemporal manner. In this paper, we describe the recent findings on the role of FilGAP in the regulation of cell morphology and migration and its regulatory mechanism.