Abstract
The pharmacological effects of synthetic vitamin K3 (2-methyl-1, 4-naphthoquinone) were studied and the following results were obtained : Initial dilation and subsequent constriction of blood vessels ; a slight rise of blood pressure; stimulation of respiratory movement; acceleration of intestinal and uterine muscle movement and marked diuresis. By a large amount of vitamin K3 there is observed inhibition of heart beat, and a fall of blood pressure. The minimal lethal dose by the subcutaneous injection is 6 mg per 10 g of body weight of mice.
