Abstract
In previous report M. Kobayashi has shown that the double-peaked time-temperature curve induced by the single injection of typhoid vaccine had been changed into a single-peaked one after repeated injections of the same pyrogen (see this Folia vol. 47, Breviaria nos. 10 and 11, 1951). The analogous facts were also proved in the case of the other pyrogens, e. g., starch, distilled water contaminated with air-born bacteria, coli vaccine and yeast extract, when applied the reduced amount of their injection. doses and also when injected repeatedly these pyrogens after heating, filtering and centrifuging. Such deformations of the fever curves are thought as concerned with the tolerance acquired by the animal against each pyrogen.
