Abstract
When the distilled water containing the culture-media centrifuges of Escherichia coli communis or Eberthella typhosa, was perfused through the liver excised from a rabbit which had acquired tolerance by the daily intravenous injection of the same pyrogen for 10 days, ther occurred the early induced single-peaked time-temperature curve when tested with another intact rabbit which has received the perfusate injection, while in the case of the same perfusion experiment through the liver of the normal rabbit the delayed single-peaked curve was induced by the coli culture-media and the double-peaked one by the Eberthellan culture-media. It is suggested that there exists two kinds of factor in each pyrogen, the one provoking the early induced single-peaked curve and the other the delayed single-peaked, and the latter f actor would be easily destroyed and/or converted readily into the former factor during the perfusion through the liver. Again, vitamin C was found effective in converting the fever curve, into the early started single-peaked form.
