Abstract
There were many sweet compounds in m-nitroaniline derivatives, but among them many toxic compounds were found. Symptoms of this poisoining and its lethal dose (LD 50) were observed in mice, and the influence on respiration and blood pressure was investigated in rabbits. 1. Toxicity of 2-amino-4-nitrophenol alkyl ethers increased in accordance with solubilities of these hydrochloride salts. 2. It was recognized that m-nitroaniline induced the toxic effect on blood and liver, while 2-amino-4-nitrotoluene induced the toxic effect on the liver and 2-amino-4-nitrophenol alkyl ethers on nervous system. 3. 2-amino-4-nitrophenol was most soluble in above mentioned compounds, but the toxic effect was relatively slight. It seemed that this was due to the easily combining quality of the phenolic OH group with the glucuronic acid or sulphuric acid which was easy to be detoxicated. 4. It seemed that the toxic effect of 2-amino-4-nitrophenol alkyl ethers were caused by its phenolic alkyl ether structure rather than by its m-nitroaniline's. 5. In rabbits, a fall of blood pressure was caused and respiration was suppressed for a short time after injecting m-nitroaniline and 2-amino-4-nitrophenol methyl ether etc. After injecting 2-amino-4-nitrophenol and p-nitrophenol, blood pressure fell for a while and respiration remarkable excited. It seemed that these results were influenced by the phenolic OH group.
