Experimental studies on Poisoning of aromatic amino-and nitro-compounds

IV. Patho-histological studies on the Poisoning of m-nitroaniline derivatives

Abstract

m-Nitroaniline derivatives were given to mice Per os and internal organs of these mice were patho-histologically examined, and remarkable changes were recoginzed in the liver, kidney and spleen. The pathological findings appeared most remarkably in mice with m-nitroaniline, but were weakened in mice with alkyl ethers. Therefore it seemed that these toxic effects were weakened when OH and O.R group attached to para-position against nitro-group of m-nitroaniline.