Abstract
Four adenosine derivatives, viz. ATP, ADP, AMP and adenosine, were studied with regard to their pharmacological action on muscles, particularly on isolated smooth muscles. The stimulating action on uterus and relaxing effect on intestine were found to be common to all these adenosine derivatives. The following effects, however, could be obtained only by ATP and ADP : the contraction of intestine and frog's M. rectus abdominis, and the accelerating effect on acetylcholine contraction of the latter. Ergotamine and ergometrine were shown to have a specific accelerating effect on the stimulating action of adenosine derivatives on hamster uterus.
