Abstract
The authors observed the influences of such muscle relaxants as d-tubocurarine, etc. upon the gaseous metabolism. By the administration of 0.14 to 0.28 mg of d-tubocurarine chloride per kg of body weight, the gaseous metabolism of rats was inhibited for a comparatively long time, Rig rose, and the body temperature dropped markedly. By 0.02 to 0.05 mg/kg of dimethyl-tubocurarine iodide, the gaseous metabolism was inhibited and the body temperature remained dropped for a long time. By 1.0 to 4 mg/kg of decamethonium, the gaseous metabolism. was, checked and R.Q. and the body temperature fell. When given in doses of 0.25 mg/kg or more, tetrodotoxin (fugu-toxin, a poison of the globe-fish species) inhibited the gaseous metabolism and made the body temperature drop, although those metabolic changes varied more or less in their degree according to a dose of the drug to be administered. When administered in doses of 25 mg/kg or more, mephenesin inhibited the gaseous metabolism for a long while and caused a persisting fall of the body temperature.
