Abstract
The insulin content of the pancreas was determined in dogs and rats which were administered calcium mesoxalate continuously for a prolonged period. 1) The insulin content of the pancreas increased in rats given daily oral doses of 100 mg/kg for 1, 3, 6 and 12 months. The effect of the drug reached the maximum level after 3 months. 2) The pups, 3-6 kg body weight, were.given daily oral doses of 10 mg/kg and 50 mg/kg for 2 and 6 months. After 2 months the insulin content of the pancreas increased to nearly twice the normal value, but after 6 months there was no significant deviation from the normal pattern. Variance by sex was negligible. 3) The male dogs, 10-15 kg body weight, were given daily doses of 50 mg/kg and 200 mg/kg for 1 and 2 months. The maximum effect occurred in the group of dogs administered doses of 200 mg/kg for 1 month, the insulin content rising to two and half times the normal value. But there was no significant deviation from the normal pattern in the group of dogs administered doses of 50 mg/kg for 2 months.
