Abstract
The hemostatic effect of Menaquinone-4 (K2) on bleeding at partially incised tail vein of rats pretreated with Dicumarol, Urokinase or Carbon Tetrachloride to prolong definitely bleeding time was studied. The effect of K2 on the bleeding was compared with the effects of Phytonadion (K1), Etamsylate, Tranexamic Acid (AMCHA), Epsilone Aminocaproic Acid (EACA) and Carbazochrome (CA-17).
Intramuscularly administered K2, K1 and AMCHA showed statistically significant effect on shortening bleeding time on the rats given Dicumarol but K2 was the most potent. The bleeding time on K2-administered rats pretreated with Carbon Tetrachloride was significantly shortened, but K1 showed no effect. The bleeding time on the rats given Urokinase was apparently reduced by AMCHA, while K2 and K1 were not significantly effective.
