Folia Pharmacologica Japonica
Online ISSN : 1347-8397
Print ISSN : 0015-5691
ISSN-L : 0015-5691
Study on hypercoagulability of Menaquinone-4 (K2) in normal rabbits
Tetsuya TAJIMAToshiharu OHGOHKohei MIYAO
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1971 Volume 67 Issue 5-6 Pages 486-493

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Abstract
Normal rabbits with 2.5-3.0kg body weight were intramuscularly injected 50mg/kg of K2 which was correspond to 100-300 fold of clinical dosage for human, and then, prothrombin time and thrombelastogram on blood of the rabbits were observed daily for 7 days. During this term, the prothrombin time and the thrombelastogram were little changed. Serum bilirubin of the rabbits showed normal level under this condition.
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© The Japanese PharmacologicalSociety
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