Abstract
Anti-inflammatory assay by carboxymethyl cellulose pouch method, 2, 5) which is suitable for assaying leucocyte infiltration in the inflammatory reaction induced by CMC solution, was applied to test the action of clonixin, indomethacin, phenylbutazone and hydrocortisone acetate. These drugs were given locally together with 1.5% CMC solution on the dorsum of rats.
Clonixin in a high dose (130mg/kg) gave 91.3% inhibition and 47.3% inhibition in a low dose (16.0mg/kg). Indomethacin and phenylbutazone showed significant inhibitory effect without giving clear dose-response relationship. Inhibition by these two drugs did not exceed a maximum of 50%. Hydrocortisone acetate (10mg/kg) gave 81.8% inhibition.
