Abstract
Inhibitory action of Clonixin, 2-(2'-methyl-3'-chloro)-anilinonicotinic acid, on the carrageenin edema and acetic acid edema of the rat paw was tested. It was somewhat more potent than aspirin. Analgesic action was tested on pressure pain on the mouse tail, writhing movements of mice treated with diluted acetic acid and pressure pain on carrageenin-inflamed rat's paw. It was proved 1.5 to 3 times more potent than aspirin. It had an inhibitory action on capillary permeability of mice peritoneal cavity and antipyretic action.
Clonixin aggravated acetic acid ulcer produced on the rat stomach. It produced musculotropic contraction of isolated ileum of the guinea pig and at the same time weak papaverine-like non-competitive antispasmodic action.
