Abstract
Behavioral effects of lithium chloride (LiCl) were investigated and compared with those of chlorpromazine as observed in rats and mice. In mice, LiCl decreased exploratory behavior, suppressed conditioned avoidance response, reduced fighting which had been induced by either long term isolation or foot shock, inhibited abnormal behavior induced by methamphetamine, apomorphine and mescaline, potentiated the effects of hypnotics and anesthetics, and induced catalepsy in mice at extremely large doses. These behavoral effects of LiCl were in general similar to those seen with chlorpromazine. LiCl, however, was different from chlorpromazine in the following respects ; i. e. aggressive behavior of the rat induced by either septal lesions or olfactory bulb ablations was not significantly suppressed and convulsion was not exaggerated with LiCl.
