Abstract
We investigated the mechanims of interaction between lead acetate (Pb-Ac) and bone minerals. One hundred and eighteen male rats were used and the following experiments were carried out: (1) determination of changes in serum Ca and P following intravenous injection of Pb-Ac or sodium acetate(Na-Ac) as the control for acetate, (2) to ascertain the deposition of lead at the calcifying site of bone immediately after Pb-Ac administration. The serum Ca and P levels increased with time after Pb-Ac administration and the maximum values were noted after 1 hour in Ca (17 mg%) and 30 minutes in P (13.5mg%), respectively. Both Ca and P levels reverted to the normal range within 12 hours. The net increasing rates in both Ca and P were calculated from each value in the Pb-Ac and Na-Ac groups. Those maximum rates were found immediately after the Pb-Ac administration (0 ?? 30 sec). At the same time, deposition of lead was evident at the calcifying site of bone and insicor dentine.
