Decision of Intracellular Centrosome Hyperamplification by Using Weighted T-test for Early Detection of Bladder Cancer

Abstract

Centrosome is a tissue which evenly distributes chromosomes to two cells during cell division. There are usually two centrosomes in a cell, but some cells have more than two. This phenomenon is called centrosome hyperamplification (CH). CH affects the state of progression in bladder cancer. It is believed that CH is controled by genes. In this report, we estimate the gene regions causing CH by using the weighted t-test for DNA-microarray data. And further by applying the method based on the maximum a posteriori (MAP) to the estimated gene regions data, we distinguish the state of patient's centrosome.