Identification of growth-dependent genes involved in paraquat toxicity in Saccharomyces cerevisiae

Tsutomu Takahashi; JunXuan Zhu; Naoya Sonoda; Shusuke Kuge; Gi-Wook Hwang; Akira Naganuma

doi:10.2131/fts.1.113

Toxicomics Report

Identification of growth-dependent genes involved in paraquat toxicity in Saccharomyces cerevisiae

Tsutomu Takahashi, JunXuan Zhu, Naoya Sonoda, Shusuke Kuge, Gi-Wook Hwang, Akira Naganuma

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Keywords: Paraquat, Resistance, Yeast, UTP4, UTP25

JOURNAL FREE ACCESS

2014 Volume 1 Issue 3 Pages 113-114

DOI https://doi.org/10.2131/fts.1.113

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Abstract

Using the yeast strain library we established by overexpressing each gene essential for yeast growth, we comprehensively searched for genes affecting the sensitivity of yeast to paraquat. As a result, seven novel genes, UTP4, UTP25, SEC65, NDD1, TFB2, TIM23, and CCT6, were identified as conferring paraquat resistance in yeast via overexpression.

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