Acute hepatotoxicity induced by quetiapine fumarate in larval zebrafish

Abstract

Quetiapine fumarate (QF) is a widely used antipsychotic agent for the first-line treatment of schizophrenia, with good tolerability and compliance in humans and no observed adverse effects against liver. Taking advantages of zebrafish, which can be utilized in rapid drug screening and acute toxicity assessment, our study determined a certain hepatotoxicity of QF for the first time, indicating a potential safety hazard of this commonly used drug to humans.