Fundamental Toxicological Sciences
Online ISSN : 2189-115X
Original Article
Acute toxicity of phorate oxon by oral gavage in the Sprague-Dawley rat
Thomas H. SniderKevin G. McGarryMichael C. BabinDavid A. JettGennady E. Platoff Jr.David T. Yeung
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JOURNALS FREE ACCESS

2016 Volume 3 Issue 5 Pages 195-204

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Abstract

The oral toxicity of phorate oxon (PHO), with emphasis on gender- and age-related effects, was characterized in the Sprague-Dawley rat. The oral LD50 (95% fiducial limits) for PHO in corn oil was 0.88 (0.79, 1.04) mg/kg in males and 0.55 (0.46, 0.63) mg/kg in females with a probit slope of 15. Females had higher baseline blood cholinesterase titers, but males were significantly more tolerant. Younger rats generally had lower absolute cholinesterase blood titers. However as PHO challenges increased, baseline-normalized cholinesterase inhibition was independent of age and gender. Butyrylcholinesterase (BChE) and especially acetylcholinesterase (AChE) in brains of younger females were affected more than that in either males or older females. In summary, while female rats, especially older females, had higher titers relative to males, female rats were more susceptible in terms of absolute cholinesterase inhibition and 24-hr lethality data, but the differences were not observed when titers were normalized to baseline levels.

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© 2016 The Japanese Society of Toxicology
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