Abstract
The patient was a 57-year-old male. Upper gastrointestinal endoscopy revealed an irregular erosion adjacent to a reddish area on the left side wall of the cervical esophagus. Biopsy specimens histologically indicated esophageal adenocarcinoma arising from the heterotopic gastric mucosa, and a subtotal esophagectomy was performed. Immunohistochemical examinations for MUC5AC, MUC6, MUC2, and Cdx2 were performed, the cancerous lesion was positive for MUC5AC, MUC6, MUC2, and Cdx2, and the background mucosa (heterotopic gastric mucosa) was positive for MUC5AC, MUC6 and Cdx2. Thus, this tumor was considered to be derived from the heterotopic gastric mucosa, with intestinal metaplasia. The case of cervical esophageal adenocarcinoma arising from the heterotopic gastric mucosa is very rare, and to our knowledge only 18 cases including our case have been reported in Japan.
