Abstract
The mucosal prolapse syndrome (MPS) is caused by the excessive mechanical stimulus of ‘straining’ at the time of chronic constipation and defecation. The basic medical treatment of MPS is to normalize the defecation. No report has as yet suggested that endoscopic mucosal resection would be effective, although there have been reports in which surgical therapy was effective. We performed endoscopic submucosal dissection (ESD) in two MPS cases for the purpose of en-block resection and formation of a submucosal scar with fibrosis for fixation of the membrane. Post-ESD, the ulcer changed to a scar, and the clinical symptoms improved in both cases. Although ESD has not been recommended as a cure for MPS, taking the safety of the procedure into account, our findings suggest that it could become an effective and minimally-invasive treatment for those cases which have not responded to conservative treatment.
