SUPERFICIAL ESOPHAGEAL CARCINOMAS ON ESOPHAGEAL VARICES TREATED WITH ENDOSCOPIC SUBMUCOSAL DISSECTION AFTER INTRAVARICEAL ENDOSCOPIC INJECTION SCLEROTHERAPY

Abstract

We report here two cases of superficial esophageal squamous cell carcinoma (SESCC) on esophageal varices. The first case was a 59-year-old man and the second was a 47-year-old man. Both of these men had alcoholic liver cirrhosis, and they had SESCC lesions on esophageal varices diagnosed based on the results of narrow-band imaging magnified endoscopy (NBIME). The results also indicated the lesion extended into the muscularis mucosae. We removed these two tumors by ESD following intravariceal endoscopic injection sclerotherapy of underlying varices with fluoroscopic guidance (intra-EIS).
En bloc resection of the lesions was achieved without any adverse events.
Histological evaluation of the sampled specimens showed the lesions were squamous cell carcinomas that had invaded the muscularis mucosae (T1a-MM).
There was no cancer recurrence within 24 months for the first case and no recurrence within 18 months in the second case.
ESD following intra-EIS could be a reliable and safe endoscopic therapy for SESCC lesions on esophageal varices.