食道静脈瘤に対する内視鏡的硬化療法後に第V因子欠損症を来した1例

山田 和俊; 北村 和哉; 丹尾 幸樹; 島上 哲朗; 荒井 邦明; 柿木 嘉平太; 山下 太郎; 酒井 佳夫; 水腰 英四郎; 金子 周一

doi:10.11280/gee.56.451

A CASE OF ACQUIRED FACTOR V DEFICIENCY CAUSED BY ENDOSCOPIC INJECTION SCLEROTHERAPY

Kazutoshi YAMADA, Kazuya KITAMURA, Kouki NIO, Tetsuro SHIMAGAMI, Kuniaki ARAI, Kaheita KAKINOKI, Taro YAMASHITA, Yoshio SAKAI, Eishiro MIZUKOSHI, Shuichi KANEKO

Author information

Kazutoshi YAMADA
Department of Gastroenterology, Kanazawa Unniversity Graduate School of Medical Science.
Kazuya KITAMURA
Department of Gastroenterology, Kanazawa Unniversity Graduate School of Medical Science.
Kouki NIO
Department of Gastroenterology, Kanazawa Unniversity Graduate School of Medical Science.
Tetsuro SHIMAGAMI
Department of Gastroenterology, Kanazawa Unniversity Graduate School of Medical Science.
Kuniaki ARAI
Department of Gastroenterology, Kanazawa Unniversity Graduate School of Medical Science.
Kaheita KAKINOKI
Department of Gastroenterology, Kanazawa Unniversity Graduate School of Medical Science.
Taro YAMASHITA
Department of Gastroenterology, Kanazawa Unniversity Graduate School of Medical Science.
Yoshio SAKAI
Department of Gastroenterology, Kanazawa Unniversity Graduate School of Medical Science.
Eishiro MIZUKOSHI
Department of Gastroenterology, Kanazawa Unniversity Graduate School of Medical Science.
Shuichi KANEKO
Department of Gastroenterology, Kanazawa Unniversity Graduate School of Medical Science.

JOURNAL FREE ACCESS

2014 Volume 56 Issue 3 Pages 451-456

DOI https://doi.org/10.11280/gee.56.451

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Abstract

We report a 57-year-old male with esophageal varices who had difficulty in hemostasis after endoscopic injection sclerotherapy (EIS). Laboratory data revealed a decrease in blood clotting, a dissociation in prothrombin activity with the hepaplastin test results, and a significant reduction in factor V (FV) activity. Therefore, we made the diagnosis of an acquired FV inhibitor. Since the patient had no unusual bleeding at the time of diagnosis, we provided careful observation with no particular treatment. Subsequently we confirmed that there was an improvement in blood clotting and a decrease in the FV inhibitor titer. We report a case of acquired FV deficiency caused by EIS, which is extremely rare.

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