A CASE OF ACQUIRED FACTOR V DEFICIENCY CAUSED BY ENDOSCOPIC INJECTION SCLEROTHERAPY

Abstract

We report a 57-year-old male with esophageal varices who had difficulty in hemostasis after endoscopic injection sclerotherapy (EIS). Laboratory data revealed a decrease in blood clotting, a dissociation in prothrombin activity with the hepaplastin test results, and a significant reduction in factor V (FV) activity. Therefore, we made the diagnosis of an acquired FV inhibitor. Since the patient had no unusual bleeding at the time of diagnosis, we provided careful observation with no particular treatment. Subsequently we confirmed that there was an improvement in blood clotting and a decrease in the FV inhibitor titer. We report a case of acquired FV deficiency caused by EIS, which is extremely rare.