2017 Volume 59 Issue 10 Pages 2535-2545
Endoscopic submucosal dissection (ESD) for superficial esophageal squamous cell carcinoma is gradually becoming the standard treatment since being covered by the Japanese national health insurance in 2008. However, post-procedural stricture is common after ESD for extensive tumors, especially among patients who underwent complete or semi-complete circular dissection. These cases are challenging as multiple endoscopic balloon dilation (EBD) procedures are required. We previously reported that systemic steroid hormone (SH) administration and cell sheet transplantation therapy reduced the frequency of EBD. In this article, we investigate the usefulness and limitations of steroid administration for prevention of post-ESD stenosis. Furthermore, we clarify the usefulness of SH oral + local injection combination therapy for cases that are resistant to these stenosis prevention treatments.
