悪性黒色腫に対しニボルマブ投与中に潰瘍性大腸炎類似の大腸炎を認めた１例

高山 政樹; 大原 裕士郎; 秦 康倫; 木下 大輔; 奥田 英之; 川崎 俊彦; 水野 成人; 若狭 朋子; 太田 善夫; 工藤 正俊

doi:10.11280/gee.59.450

A CASE OF ACUTE COLITIS MIMICKING ULCERATIVE COLITIS DURING NIVOLUMAB INFUSION THERAPY FOR ADVANCED MELANOMA

Masaki TAKAYAMA , Yushiro OHARA, Kan-yun HATA, Daisuke KINOSHITA, Hideyuki OKUDA, Toshihiko KAWASAKI, Shigeto MIZUNO, Tomoko WAKASA, Yoshio OTA, Masatoshi KUDO

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JOURNAL FREE ACCESS FULL-TEXT HTML

2017 Volume 59 Issue 4 Pages 450-455

DOI https://doi.org/10.11280/gee.59.450

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Abstract

An 89-year-old man with advanced melanoma was admitted to our hospital to receive additional nivolumab infusion therapy. Stomach ache, diarrhea, and bloody stools developed after nivolumab infusion. Colonoscopy showed colitis mimicking ulcerative colitis. Therefore, we diagnosed him as having an immune-related adverse event induced by nivolumab. After steroid therapy, his clinical manifestations and endoscopic findings markedly improved.

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