2020 Volume 62 Issue 12 Pages 3041-3048
[Objective] Sodium picosulfate/magnesium citrate (PICOPREPⓇ) has been reported to have higher patient tolerability and a non-inferior colorectal cleansing effect compared with polyethylene glycol preparations. However, its colorectal cleansing effect appears to be poor in actual clinical practice. This study aimed to determine whether enhanced bowel preparation improves the colorectal cleansing effect of PICOPREPⓇ while maintaining patient tolerability.
[Methods] Subjects were randomly assigned to either the PICOPREPⓇ usual administration group (P/MC group) or the enhanced pretreatment group who additionally received 5 mL of 0.75% sodium picosulfate hydrate before bedtime on the previous day (enhanced P/MC group). The primary endpoint was the degree of colorectal cleansing on the Ottawa scale, and the secondary endpoint was tolerability.
[Results] The score for the degree of colorectal cleansing was significantly lower in the enhanced P/MC group (n = 49) than in the P/MC group (n = 49; 4.6 ± 0.5 vs. 6.6 ± 0.5; P＜0.001), showing a higher degree of cleansing in the enhanced P/MC group. Patient tolerability showed no significant difference between the two groups. There were no significant differences in the rates of complications between the two groups.
[Discussion] The addition of 0.75% sodium picosulfate hydrate to PICOPREPⓇ improved its intestinal cleansing effect and maintained patient tolerability.
