2021 Volume 63 Issue 11 Pages 2343-2349
Pyloric gland adenoma is a rare neoplasm of the gastrointestinal tract that shows gastric pyloric gland differentiation and commonly occurs in the gastric body in older patients. A 78-year-old man was diagnosed with a submucosal tumor-like lesion with a well-defined depression in the anterior wall of the gastric body. White light endoscopy revealed a villous or papillary microstructures with branched extended vessels. Blue laser imaging using magnification revealed small, slightly irregular vessels. Endoscopic submucosal dissection was performed, and histopathological evaluation of the resected specimen confirmed the diagnosis of an inverted pyloric gland adenoma. An inverted pyloric gland adenoma is rare, and the lesion showed a peculiar appearance in our patient. Pyloric gland adenomas share phenotypic features with other low-grade tumors of gastric phenotype such as fundic gland type adenocarcinoma. Our case report highlights important features associated with cellular differentiation of low-grade gastric tumors and the endoscopic diagnosis of such lesions.