2021 Volume 63 Issue 4 Pages 401-406
We report a case of gastric carcinoma coexisting with Epstein-Barr virus (EBV)-associated gastric carcinoma and early gastric adenocarcinoma. A 76-year-old man visited our hospital with epigastric pain of one month’s duration. Upper gastrointestinal endoscopy revealed a wide-range type 3 tumor crossing over the upper part of the lesser curvature and the posterior wall; moreover, there was a 0-Ⅱc lesion in the anterior wall of the antrum. Following biopsy, the type 3 tumor was diagnosed as poorly differentiated carcinoma with lymphoid stroma and the 0-Ⅱc lesion was diagnosed as adenocarcinoma. Total gastrectomy was performed. EBV-encoded RNA in situ hybridization (EBER-ISH) on both lesions revealed that the type 3 tumor was EBV-positive and the 0-Ⅱc lesion was EBV-negative. We should note that the prevalence of EBV-associated gastric carcinoma is higher in multiple gastric carcinomas than in simple gastric carcinomas.
