2021 Volume 63 Issue 4 Pages 391-400
Gastric and colon cancers are common causes of cancer deaths in Japan. The risk of death from these cancers can be markedly reduced by screening gastrointestinal endoscopy. Sedation improves the acceptability of endoscopy to patients and results in a better tolerated procedure. Achieving safe and effective sedation requires an understanding of the characteristics of the medication utilized. Medications used for sedation in endoscopy include midazolam, propofol and dexmedetomidine hydrochloride. Based on the guidelines for endoscopic procedures established by the Japan Gastrointestinal Endoscopy Society, we discuss how to utilize these drugs to obtain safe and effective sedation. In addition, we discuss allergy, adverse events, and safe use of sedative medicines during and after endoscopic procedures.