2021 Volume 63 Issue 7 Pages 1351-1357
A woman in her 70s with Helicobacter pylori-positive-and-t(11;18)(q21;q21) translocation-negative gastric MALT lymphoma was successfully treated by H. pylori eradication therapy. The lymphoma presented as scarlet depressed-type lesions, in which the lesions were located on the fornix and middle part of the gastric body. Seven years after the initial examination, we could recognize a new lesion in the middle anterior wall of the gastric body on upper gastrointestinal endoscopy. The new lesion was diagnosed as H. pylori-negative-and-t(11;18)(q21;q21) translocation-positive gastric MALT lymphoma based on histopathological and genetic analyses, and the lesion was treated by radiation therapy. MALT lymphomas with different antigenicities developed metachronously in the same patient. There are no reports of such a case. This case is considered to be a valuable case for examining the clinicopathological and molecular biological background of MALT lymphoma.
