HEREDITARY DIFFUSE GASTRIC CANCER WITHOUT PROGRESSION ON 4-YEAR ENDOSCOPIC FOLLOW-UP : A CASE REPORT

Abstract

A 43-year-old man underwent annual gastrointestinal endoscopy since 2016 for surveillance of multiple small pale antral lesions, which were not evaluated histopathologically. Biopsy performed for the first time in 2020 revealed a signet-ring cell carcinoma. He underwent distal gastrectomy, and histopathological examination of the surgical specimen revealed 42 small lesions, all of which were diagnosed as carcinoma in situ. We suspected hereditary diffuse gastric cancer (HDGC) and performed genetic analysis, which revealed the CDH1 germline pathogenic variant of the cancer, and the patient was definitively diagnosed with HDGC.